Adenosine | 58-61-7

Adenosine, nucleoside inoumbwa neadenine uye ribose, ine akati wandei akakosha mashandisirwo emushonga uye physiology nekuda kwemaitiro ayo emuviri pane akasiyana masisitimu emuviri.

Cardiovascular Medicine:

Diagnostic Tool: Adenosine inoshandiswa se pharmacological stress agent panguva yekuedzwa kwemwoyo, zvakadai semyocardial perfusion imaging. Inobatsira kuongorora coronary artery chirwere nekukonzera coronary vasodilation, kutevedzera mhedzisiro yekurovedza muviri.

Kurapa kweSupraventricular Tachycardia (SVT): Adenosine ndiyo mishonga yekutanga yekugumisa zvikamu zveSVT. Inoshanda nekunonotsa conduction kuburikidza neatrioventricular node, kukanganisa nzira dzekudzoka dzinoita SVT.

Neurology:

Kubata Kudzora: Adenosine inonzi endogenous anticonvulsant muuropi. Modulating adenosine receptors inogona kuita antiepileptic effects, uye adenosine-releasing agents ari kuferefetwa sezvingangoita marapirwo epfari.

Neuroprotection: Adenosine receptors inoita basa mukudzivirira neurons kubva mukukuvara kwe ischemic uye oxidative kusagadzikana. Tsvagiridzo inoongorora kugona kweadenosine senge neuroprotective agent musitiroko uye neurodegenerative zvirwere seParkinson's neAlzheimer's.

Mushonga Wekufema:

Bronchodilation: Adenosine inoshanda sebronchodilator uye inoshandiswa mukuongororwa kwebronchoprovocation kuongorora asima. Inokonzera bronchoconstriction muvanhu vane asthma, zvichibatsira kuziva mhepo inofambisa hyperreactivity.

Antiarrhythmic Properties:

Adenosine inogona kudzvinyirira mamwe marudzi earrhythmias nekugadzirisa magetsi mukati memwoyo, kunyanya muatria uye atrioventricular node. Yayo pfupi hafu yeupenyu inogumira systemic mhedzisiro.

Chishandiso chekutsvakurudza:

Adenosine uye analogs ayo anoshandiswa zvakanyanya mukutsvagisa kudzidza basa readenosine receptors mune akasiyana physiological uye pathological maitiro. Ivo vanobatsira kujekesa mashandiro eadenosine mune neurotransmission, immune system, kuzvimba, uye kudzora kwemoyo.

Zvinogona Kurapa Zvishandiso:

Adenosine-based drug iri kuferefetwa kune inogona kurapa mashandisirwo mumamiriro ezvinhu akadai segomarara, ischemic kukuvara, marwadzo ekudzora, uye kuzvimba kusagadzikana. Adenosine receptor agonists uye vanopikisa vari pakati pemakemikari ari pasi pekudzidza.