Fludarabine | 21679-14-1

Fludarabine mushonga wechemotherapy unonyanya kushandiswa mukurapa mamwe marudzi egomarara, kunyanya hematological malignancies. Heino mhedziso:

Mechanism of Action: Fludarabine inonzi nucleoside analog iyo inokanganisa kuumbwa kweDNA neRNA. Inodzivirira DNA polymerase, DNA primase, uye DNA ligase enzymes, zvichiita kuti DNA strand iparadzwe uye inhibition yeDNA yekugadzirisa nzira. Uku kukanganisika kweDNA synthesis kunopedzisira kwakonzera apoptosis (yakarongwa sero kufa) mumasero anokurumidza kupatsanura, kusanganisira maseru egomarara.

Zviratidzo: Fludarabine inowanzoshandiswa mukurapa kwechirwere chisingaperi che lymphocytic leukemia (CLL), pamwe chete nezvimwe zvirwere zvehematological zvakadai se indolent non-Hodgkin lymphoma uye mantle cell lymphoma. Inogonawo kushandiswa mune zvimwe zviitiko zveacute myeloid leukemia (AML).

Kutonga: Fludarabine inowanzoitwa intravenously (IV) muchipatara, kunyange zvazvo inogona kupiwa nemuromo mune dzimwe nguva. Chiyero uye hurongwa hwekutonga zvinoenderana negomarara chairo riri kurapwa, pamwe nehutano hwemurwere hwese uye mhinduro pakurapwa.

Migumisiro Yakashata: Zvakajairwa nemigumisiro yefludarabine inosanganisira kudzvinyirirwa kwemwongo (zvinoita neutropenia, anemia, uye thrombocytopenia), kusvotwa, kurutsa, manyoka, fivha, kuneta, uye kuwedzera kubatwa nezvirwere. Inogonawo kukonzera zvakanyanya kuipa kwakashata senge neurotoxicity, hepatotoxicity, uye pulmonary toxicity mune dzimwe nguva.

Chengetedzo: Fludarabine inopesana nevarwere vane kudzvinyirira kwakanyanya kwemwongo kana kukanganisa renal basa. Inofanira kushandiswa nekuchenjerera kune varwere vane chiropa chisati chavapo kana chirwere chetsvo, pamwe chete nevakadzi vane pamuviri kana vanoyamwisa nekuda kwekugona kukuvadza kumwana kana mucheche.

Kupindirana Kwezvinodhaka: Fludarabine inogona kuwirirana nemimwe mishonga, kunyanya iyo inobata mwongo webasa kana renal function. Zvakakosha kuti varapi vezvehutano vatarise rondedzero yemishonga yemurwere uye vatarise kune zvingangoitika zvinodhaka.

Monitoring: Kugara uchitarisisa kuwanda kweropa uye renal basa kwakakosha panguva yekurapa nefludarabine kuongorora zviratidzo zvekudzvanywa kwemwongo kana zvimwe zvinokanganisa. Kugadziriswa kwedose kunogona kudikanwa zvichibva pane aya ekutarisa ma parameter.