Huperzine A ｜120786-18-7

Huperzine A inyanzvi yekuziva inodzivisa ma enzymes anokanganisa kudzidza neurotransmitter acetylcholine. Iyo ndeyecholinergic kirasi yemamorekuru inogona kubatsira kurwisa kuderera kwekuziva kune vakura.

Huperzine A musanganiswa wakatorwa kubva kumhuri yehuperzine. Inonzi acetylcholinesterase inhibitor, zvinoreva kuti inodzivirira enzyme kubva pakuputsa acetylcholine, zvichiita kuti kuwedzerwa kweacetylcholine.

Acetylcholine inodaidzwa kunzi neurotransmitter yekudzidza uye inobatanidzwawo mukumanikana kwemhasuru.

Huperzine A inoratidzika kunge iri musanganiswa wakachengeteka. Toxicity uye zvidzidzo zvevanhu kubva kuzvidzidzo zvemhuka zvakaratidza kuti hapana mhedzisiro payakajairwa madosi ekuwedzera. Huperzine A iri kushandiswawo mukuedzwa kwekutanga kudzivirira chirwere cheAlzheimer.

Huperzine A inoitika mucerebrospinal fluid uye inoyambuka zviri nyore ropa-brain barriers.

Huperzine A inonyanya kuzivikanwa seacetylcholinesterase inhibitor. Kunyanya, inodzivirira iyo G4 subtype yeacetylcholinesterase, iyo inowanikwa muhupfungwa hwemammalian. Inonyanya kushanda kana zvakaenzana kurwisa mamwe acetylcholinesterase inhibitors, senge tacillin kana rivastatin. Se inhibitor, ine hukama hwepamusoro hweacetylcholinesterase. Panguva imwecheteyo, ine inononoka dissociation nguva dzose, iyo inoita kuti hafu yehupenyu hurebe.

Pamusoro pekudzivisa acetylcholinesterase, inogonawo kuonekwa seyeuroprotective inopikisa glutamate, beta amyloid pigmentation, uye H2O2-induced toxicity.

Huperzine A inogona kukurudzira kuwanda kweiyo hippocampal neural stem masero (NSCs). Zvinoita sekusimudzira nerve kukura pabiorelated doses.