Mitomycin C | 50-07-7

Mitomycin C mushonga wechemotherapy unoshandiswa zvakanyanya mukurapa marudzi akasiyana egomarara. Ndeyekirasi yemishonga inozivikanwa seantineoplastic antibiotics. Mitomycin C inoshanda nekukanganisa kukura uye kudzokororwa kwemasero egomarara, zvichizokonzera kufa kwavo.

Heano mamwe mapoinzi akakosha nezveMitomycin C:

Mechanism of Action: Mitomycin C inoshanda nekusunga kuDNA nekudzivisa kudzokorora kwayo. Inoyambuka-inobatanidza tambo dzeDNA, ichidzidzivirira kubva pakuparadzana panguva yekuparadzaniswa kwesero, izvo zvinozotungamira kurufu rwesero.

Zviratidzo: Mitomycin C inowanzoshandiswa kurapa mamwe marudzi egomarara, kusanganisira kenza yemudumbu (gastric), kenza yepancreatic, kenza yekumashure, kenza yedundira, uye mamwe marudzi ekenza yemapapu. Inogona zvakare kushandiswa pamwe chete nemamwe chemotherapy mishonga kana radiation therapy.

Kutonga: Mitomycin C inowanzoitwa intravenously nenyanzvi yehutano munzvimbo yekiriniki yakadai sechipatara kana infusion centre.

Maside Effects: Zvinowanzoitika mhedzisiro yeMitomycin C inogona kusanganisira kusvotwa, kurutsa, manyoka, kuneta, uye kuderera kwemasero eropa (anemia, leukopenia, thrombocytopenia). Izvo zvinogona zvakare kukonzera zvakakomba mhedzisiro senge bone marrow kudzvanywa, itsvo toxicity, uye pulmonary toxicity.

Chengetedzo: Nekuda kwekugona kwayo kuita huturu, Mitomycin C inofanirwa kushandiswa nekuchenjerera, kunyanya kune varwere vane itsvo dzisati dzavapo kana matambudziko echiropa. Varwere vanogamuchira Mitomycin C vanofanira kunyatsoongororwa zviratidzo zvemigumisiro yakaipa.

Kushandiswa muCancer Kurapa: Mitomycin C inowanzoshandiswa sechikamu chemusanganiswa wechemotherapy regimens kana pamwe chete nemamwe marapirwo ekenza kuvandudza migumisiro kune varwere vane marudzi akasiyana-siyana ekenza.