Tacrolimus | 104987-11-3

Tacrolimus, inozivikanwawo nezita rayo rekutengesa Prograf pakati pevamwe, mushonga une simba wekudzivirira muviri unoshandiswa kunyanya mukuisirwa nhengo kudzivirira kurambwa.

Mechanism of Action: Tacrolimus inoshanda nekudzivisa calcineurin, protein phosphatase inoita basa rakakosha mukushandiswa kweT-lymphocytes, ari masero ekudzivirira anobatanidzwa mukurambwa kwegraft. Nekudzivisa calcineurin, tacrolimus inovhara kugadzirwa kwepro-inflammatory cytokines uye inodzivirira kushandiswa kweT-cells, nokudaro ichidzvinyirira maitiro ekudzivirira zvirwere kune nhengo yakasimwa.

Zviratidzo: Tacrolimus inoratidzwa nokuda kweprophylaxis yekurambwa kwenhengo muvarwere vanogamuchira allogeneic chiropa, itsvo, kana moyo. Inowanzoshandiswa pamwe chete nemamwe immunosuppressive agents akadai se corticosteroids uye mycophenolate mofetil.

Kutonga: Tacrolimus inowanzo kupihwa nemuromo nenzira yemacapsules kana mhinduro yemuromo. Inogona zvakare kupihwa intravenously mune mamwe mamiriro ekiriniki, senge panguva yekukurumidza mushure mekutapurirana.

Monitoring: Nekuda kweiyo nhete yekurapa indekisi uye kusiyanisa mukunyudzwa, tacrolimus inoda kunyatsotarisisa mazinga eropa kuti ive nechokwadi chekurapa kwekurapa uku ichideredza njodzi yehupfu. Kuongororwa kwemishonga yekurapa kunosanganisira kuyerwa nguva dzose kwetacrolimus mazinga eropa uye kugadziriswa kwedosi zvichienderana nemazinga aya.

Migumisiro Yakashata: Zvinowanzoitika migumisiro ye tacrolimus inosanganisira nephrotoxicity, neurotoxicity, hypertension, hyperglycemia, kuvhiringidzika kwematumbo, uye kuwedzera kubatwa nehutachiona. Kushandiswa kwenguva refu kwe tacrolimus kunogonawo kuwedzera njodzi yekuva nezvimwe zvirwere, kunyanya kenza yeganda uye lymphoma.

Kudyidzana Kwezvinodhaka: Tacrolimus inoshandiswa zvakanyanya ne cytochrome P450 enzyme system, kunyanya CYP3A4 uye CYP3A5. Naizvozvo, mishonga inokonzeresa kana kumisa ma enzymes aya inogona kukanganisa tacrolimus mazinga mumuviri, izvo zvinogona kutungamira mukukundikana kwekurapa kana muchetura.

Mafungiro Akakosha: Tacrolimus dosing inoda munhu mumwe nemumwe zvichienderana nezvinhu zvakaita sezera remurwere, uremu hwemuviri, kushanda kwetsvo, kupindirana kwemishonga, uye kuvapo kwe-co-morbidities. Kunyatsotarisisa uye kugara uchitevera nevarapi vehutano kwakakosha pakugadzirisa kurapa uye kuderedza mhedzisiro yakaipa.