Uridine | 58-96-8

Uridine inonzi pyrimidine nucleoside inoshanda sechinhu chakakosha chekuvaka cheRNA (ribonucleic acid), imwe yemhando mbiri huru dze nucleic acids dzakakosha pakuchengetedza uye kutapurirana ruzivo rwemajini mumasero.

Chemical Structure: Uridine ine pyrimidine base uracil yakanamatira kune mashanu-carbon sugar ribose kuburikidza ne β-N1-glycosidic bond.

Biological Basa:

RNA Building Block: Uridine chinhu chakakosha cheRNA, iyo inoumba musana wemamorekuru eRNA padivi pemamwe nucleosides akadai seadenosine, guanosine, uye cytidine.

Mutumwa RNA (mRNA): MumRNA, masara euridine anoisa ruzivo rwemajini panguva yekunyora, akatakura mirairo kubva kuDNA kuenda kumuchina weprotein synthesis muchitokisi.

Shandura RNA (tRNA): Uridine iripo zvakare intRNA mamorekuru, apo inotora chikamu mushanduro yekushandura nekuziva macodon chaiwo uye kuendesa inoenderana amino acids kune ribosome.

Metabolism: Uridine inogona kugadzirwa de novo mukati memasero kana kuwanikwa kubva kune zvekudya. Inogadzirwa kuburikidza nekushandura enzymatic ye orotidine monophosphate (OMP) kana uridine monophosphate (UMP) mu pyrimidine biosynthesis nzira.

Physiological Kukosha:

Neurotransmitter Precursor: Uridine inobata basa muhuropi basa uye kukura. Ndiyo inotangira kuumbwa kweuropi phospholipids, kusanganisira phosphatidylcholine, iyo inokosha kune neuronal membrane kutendeseka uye neurotransmitter chiratidzo.

Neuroprotective Effects: Uridine yakadzidzwa nekuda kwayo inogona kuita neuroprotective zvivakwa uye kugona kwayo kuwedzera synaptic basa uye neuronal plasticity.

Therapeutic Potential:

Uridine uye zvinobva pairi zvakaongororwa kuti zvigone kurapwa mumatambudziko etsinga, kusanganisira chirwere cheAlzheimer uye kusagadzikana kwepfungwa.

Uridine supplementation yakaongororwa senzira yekutsigira basa rekuziva uye kuderedza zviratidzo zvine chekuita nezvirwere zveurourodegenerative.

Zvokudya Zvokudya: Uridine inowanikwa muzvokudya zvakasiyana-siyana, kusanganisira nyama, hove, miriwo, uye zvigadzirwa zvemukaka.